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A combination of vitamins C and B1 with corticosteroids didn't prevent organ failure in septic shock, the ACTS trial showed.
The intervention improved the Sequential Organ Failure Assessment (SOFA) score 4.7 points compared with a 4.1-point improvement with placebo over the 72 hours after enrollment, which was not significant at P=0.12 for interaction, reported Michael Donnino, MD, of Beth Israel Deaconess Medical Center in Boston, and colleagues in JAMA.