ARDS and ALI

Ventilation strategy using low tidal volumes, recruitment maneuvers, and high PEEP for ARDS/ALI (RCT)

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Jan 242008

Meade MO et al. (Lung open ventilation study investigators) Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA 2008; 299:637-45. Higher PEEP provided no benefit in 28-day mortality (28 vs 32%, p = 0.2), although it reduced refractory hypoxia (~5% [… read more]

Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome

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Aug 242004

Brower RG et al. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med 2004;351:327-36. Randomized trial among 549 patients with ARDS/ALI conducted by NHLBI/ARDSNet. Compared high and low PEEP strategies, and found no significant difference in mortality, ventilator-free days, ICU-free days, or organ failure-free days between [… read more]

One-year outcomes in survivors of the acute respiratory distress syndrome

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May 242003

Herridge MS et al. One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med. 2003; 348:683-93. Non-pulmonary problems are usually dominant in impairment of ARDS survivors. Low exercise tolerance, fatigue, and weakness are common a year after discharge. Pulmonary function tests usually normalized, other than a diffusion impairment. At 12 months, only 6% [… read more]

Ventilation with lower tidal volumes as compared with traditional tidal volumes for ALI and ARDS

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Jul 242000

ARDS Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for ALI and ARDS. N Engl J Med 2000;342:1301-8. The ARMA study found the use of low (6 ml/kg predicted weight) rather than “standard” (12 ml/kg predicted weight) tidal volumes reduced mortality from 40 to 30%. This paper established the standard of low [… read more]

Interobserver variability in applying a radiographic definition for ARDS

ARDS and ALI, Critical Care, Radiology & Imaging Add a Comment

Apr 241999

Rubenfeld GD, Caldwell E, Granton J, et al. Interobserver variability in applying a radiographic definition for ARDS. Chest 1999;116:1347-53. Interobserver agreement was only moderate for diagnosing ARDS among 21 experts using consensus radiographic criteria.

Clinical risks for development of ARDS

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Oct 241995

Hudson LD et al. Clinical risks for development of ARDS. Am J Respir Crit Care Med 1995;151:293-301. Incidence of ARDS in patients with various risk factors. Showed that ARDS develops within 48 to 72 hours of the time clinical risk is identified in the vast majority of patients.