Feb 222017
 
Simple qSOFA score predicts sepsis as well as anything else

Sepsis is sneaky. Physicians, nurses, and epidemiologists struggle to accurately identify patients with sepsis in the emergency department, hospital ward, and in data sets. The so-called SIRS criteria were abandoned as insensitive and nonspecific in the most recent iteration of sepsis care. Sepsis is instead now defined as “life-threatening organ dysfunction caused by a dysregulated [… read more]

Feb 152017
 
Oxygen saturation in critical illness: could low-normal be best?

Oxygen is essential for life, but by forming superoxides and free radicals, supplemental oxygen can also inflict damage on lung and other body tissues. The sweet spot for oxygen delivery in critically ill patients is unknown, but increasing evidence suggests that when it comes to blood oxygen saturation during critical illness, “normal” levels might actually [… read more]

Feb 142017
 
A Primer on the Perils of Intravenous Fluids – Part 2

Jon-Emile S. Kenny [@heart_lung] Read part 1 here Fluids and the Glycocaylx Critically-ill patients all likely have endothelial dysfunction to some degree.  This perturbation in microvascular physiology may be underpinned by abnormal glycocalyx structure and function.  Sepsis, trauma, surgery and ischemic insults are all known to disrupt the glycocalyx which will increase vascular fluid capacitance.  [… read more]

Feb 132017
 
A Primer on the Perils of Intravenous Fluids – Part 1

Jon-Emile S. Kenny [@heart_lung] “To every (wo)man is given the key to the gates of heaven. The same key opens the gates of hell.  And so it is with science.” -Richard Feynman A rich, frosty wind etherizes my face; this cool gust rips through the medieval, labyrinthine passageways of Old Stockholm like frayed edges of [… read more]

Feb 092017
 
Reslizumab (CINQAIR) worked as add-on treatment for severe asthma with eosinophilia

Reslizumab (CINQAIR) is a humanized, anti-IL-5 biologic agent approved by FDA in March 2016 as add-on treatment for asthma with peripheral blood eosinophilia, uncontrolled by usual treatments. In two randomized trials, reslizumab improved lung function and asthma symptoms in patients meeting these criteria. Patients without high eosinophil count in peripheral blood did not experience clinically [… read more]

Feb 082017
 
Early renal replacement therapy in critical illness did not improve outcomes (AKIKI)

When is the optimal time to initiate renal-replacement therapy in the ICU? Patients with acute renal failure (a.k.a. acute kidney injury or AKI) in the ICU experience worse outcomes than patients who do not. As the kidneys shut down, toxic electrolytes and metabolic waste products build up in the blood. Intuition says — screams, really [… read more]

Feb 022017
 
CDC Releases Ventilator-Associated Events Criteria

A new term has been coined by the Centers for Disease Control and Prevention, ventilator-associated events (VAEs)¹. In 2011, the CDC convened a working group composed of members of several stakeholder organizations to address the limitations of the definition of ventilator-associated pneumonia (VAP) definition². The organizations represented in the Working Group include: the Critical Care [… read more]

Feb 012017
 
Passive leg raise test: helpful maneuver, or ICU parlor trick?

Patients who arrive at the hospital with hypotension will almost all receive intravenous fluid resuscitation (one hopes). When signs of hypoperfusion occur later in a patient’s hospital course, it can be much harder to decide if additional fluid will be helpful. Physical exam is unreliable, and no available technology can accurately identify how much water is [… read more]

Feb 012017
 
Advanced Critical Care Simulation Conference: Feb 17-18 in Phoenix (Register)

Register Now! PulmCCM is not affiliated with Banner University or the University of Arizona. SHARPEN YOUR LIFE-SAVING CRITICAL-CARE SKILLS Focusing on the clinical situations of highest concern to bedside intensivists, including the emergency evaluation of the patient with undifferentiated shock, the failed airway, refractory ARDS and obstetrical code arrest, this conference will bring participants up-to-date [… read more]

Jan 282017
 
Last chance to apply for the ALiEM Faculty Incubator

Junior faculty members: Looking for a way to bolster your academic credentials and engage/network with an established community of medical educators? The ALiEM (Academic Life in Emergency Medicine) Faculty Incubator is a yearlong online faculty development program (limited to 30 participants yearly), nearly exclusively done with online asynchronous interactions through the Slack platform. The incubator [… read more]

Jan 242017
 
2016 Surviving Sepsis Guidelines: A Review and Analysis

By Jon-Emile S. Kenny [@heart_lung] PulmCCM is not affiliated with or endorsed by the Society of Critical Care Medicine or the Surviving Sepsis Campaign. Click here to read the Surviving Sepsis Guidelines. “I am at the moment writing a lengthy indictment against our century.  When my brain begins to reel from my literary labors, I make [… read more]

Jan 182017
 
Azithromycin was no help in asthma exacerbations (AZALEA)

Adding azithromycin to usual treatment for asthma exacerbations in adults did not improve asthma symptoms or speed their resolution, investigators reported in the AZALEA randomized clinical trial. Patients getting azithromycin also had no improvement in lung function. Azithromycin is known to have some activity against viruses that infect bronchial cells; viruses are causative or contributory [… read more]

Jan 112017
 
ICU Physiology in 1000 Words: Hidden Hemodynamics in Respiratory Mechanics

Jon-Emile S. Kenny MD [@heart_lung] Hemodynamic assessment, by any means, demands a shrewd familiarity with mechanical heart-lung interaction.  The two ventricles communicate in series and in parallel; each ventricle’s pressure-volume characteristics and loading conditions pulsate between systole and diastole.  And around the heart and pericardium lies the respiratory pump – the lungs within the thorax [… read more]

Dec 242016
 
Pneumonia or Atelectasis?  Here's a trick to tell them apart

By Jon-Emile S. Kenny [@heart_lung] “New York is cold, but I like where I’m living … There’s music on Clinton Street all through the evening.” -Leonard Cohen It’s the end of December; we collectively reflect on the year that was and try to find our footing for the next.  In the short winter days of 2016, it [… read more]

Dec 162016
 
Inferior vena cava filters are overused. What's the harm?

Inferior vena cava filters (IVCF) are placed to prevent deep venous thromboses (DVT) from traveling to the heart and lungs, causing pulmonary embolism (PE). IVC filters’ rationale makes sense, but despite their wide use, the benefits and risks of IVCF remain unclear. With about 50,000 IVC filters placed annually in the U.S., that’s a lot of unclarity. [… read more]

Dec 072016
 
New 2017 GOLD Guidelines for COPD Released

The Global Initiative for Obstructive Lung Disease (GOLD – because GIOLD sounded weird) is an international collaboration of experts in chronic obstructive pulmonary disease (COPD). Every so often the GOLD gang releases another update of their standard-setting GOLD guidelines. (Read PulmCCM’s 2014 GOLD guideline review and our COPD Review.) Get the full 2017 GOLD guidelines or the 36 page [… read more]

Dec 012016
 
ICU Physiology in 1000 Words: The Folly of Pulmonary Vascular Resistance

By Jon-Emile S. Kenny [@heart_lung] When interpreting hemodynamic studies of drugs which – potentially – alter the resistance of the pulmonary vascular tree, we often turn to the calculated pulmonary vascular resistance [cPVR] as our guide.  For instance, a vasopressor determined to increase the cPVR is wholly avoided in a patient with pulmonary arterial hypertension.  We [… read more]

Dec 012016
 
Targeted molecular therapies for non-small cell lung cancer: Clinical Update

For too long, treatment for advanced non-small cell lung cancer was brutally simple: platinum chemotherapy and a trip to the attorney to get one’s affairs in order. Fortunately for patients, it’s not quite so straightforward anymore. Effective targeted molecular therapies for non-small cell lung cancer are now available, often taken orally with fewer side effects than traditional cytotoxic [… read more]

Nov 252016
 
Life-sucking power of electronic health records measured, reported, lamented

Feel like you spend twice as much time on your electronic health record as you do with patients? You may be doing better than half of your colleagues. In a new work study funded by the American Medical Association, researchers observed 57 physicians in internal medicine, family medicine, cardiology, and orthopedics over hundreds of hours. They discovered [… read more]