Sleep, Obesity-related disease Archives - Page 3 of 3 - PulmCCM
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Sleep, Obesity-related disease Articles

Augmentation common during treatment for restless legs syndrome

 Sleep, Obesity-related disease  Comments Off on Augmentation common during treatment for restless legs syndrome
May 272011
 

Allen et al surveyed 266 people under treatment for RLS for symptoms of augmentation. Fully 20% treated for ~2.7 years had definite or very likely augmentation; only 25% were completely free of augmentation symptoms, as assessed using NIH guidelines. Sleep Med 2011;12:431-439.

Adaptive ventilation improved complex sleep apnea in CHF patients

 Clinic and Consults, Sleep, Obesity-related disease  Comments Off on Adaptive ventilation improved complex sleep apnea in CHF patients
May 252011
 

Bitter et al performed CPAP titration on 192 patients with congestive heart failure and obstructive sleep apnea, unmasking residual central sleep apnea (so-called complex sleep apnea) in 34 (18%). Providing adaptive servoventilation (dynamic delivery of pressure support to achieve a target minute ventilation) improved AHI, NYHA class, BNP levels, ejection fraction, and other variables, at ~1 year [… read more]

CPAP for OSA after stroke improved neuro outcome, reduced cardiovascular risk

 Cardiovascular Disease, Randomized Controlled Trials, Sleep, Obesity-related disease  Comments Off on CPAP for OSA after stroke improved neuro outcome, reduced cardiovascular risk
May 092011
 

Parra et al diagnosed OSA in 140 patients hospitalized for stroke in Spain and randomized them to nasal auto-titrating CPAP or no therapy. The CPAP-treated patients had better Rankin and Canadian stroke outcome scores at all follow-up visits. They had the same rate of subsequent cardiovascular events, but events occurred at a median 15 months [… read more]

Apr 282011
 

Patients taking pramipexole for 6 months had a 14-point fall in their IRLS score, and 59% “responded” (had at least a 50% fall in their score). But time worked well, too: placebo patients had an 11-point decline in scores and 43% responded. So 1 in 6 responded to pramipexole, practically speaking (they don’t say this, [… read more]

Biggest losers shed 22 pounds in Qnexa weight loss drug trial

 Randomized Controlled Trials, Sleep, Obesity-related disease  Comments Off on Biggest losers shed 22 pounds in Qnexa weight loss drug trial
Apr 252011
 

Fen-phen died in court, but phenteramine was cleared of all serious charges. Gadde et al report phase III results for Qnexa (by Vivus), a phenteramine-topiramate combination. Over 56 weeks, takers of a double-dose of study drug lost 10 kg; single-dose, 8 kg; and placebo, 1.4 kg. There were plenty of side effects (dry mouth and paresthesias [… read more]

Sleep disordered breathing plus daytime somnolence associated with early death in elderly

 Sleep, Obesity-related disease  Comments Off on Sleep disordered breathing plus daytime somnolence associated with early death in elderly
Apr 212011
 

Gooneratne et al selected 289 people over 65 (nondemented, nondepressed), half of whom had excessive daytime sleepiness (EDS). All got polysomnograms and were followed for a mean of 14 years. Those with EDS and sleep disordered breathing (SDB) had a hazard ratio for mortality of 2.7, that fell to 2.3 after adjusting for covariates. People [… read more]

CPAP adherence after home sleep testing was equal to in-lab PSG

 Sleep, Obesity-related disease  Comments Off on CPAP adherence after home sleep testing was equal to in-lab PSG
Apr 032011
 

Lettieri et al prospectively observed 210 patients with obstructive sleep apnea, who were diagnosed & titrated in-lab or at home. Those who were diagnosed and titrated at home and managed through their primary care clinic had equivalent adherence with CPAP therapy (~70% of nights; ~4.5 hrs/night; regular use ~52%) to those diagnosed and titrated in-lab [… read more]

Obstructive sleep apnea didn’t depress cognitive function

 Sleep, Obesity-related disease  Comments Off on Obstructive sleep apnea didn’t depress cognitive function
Mar 302011
 

Re-heating data from the APPLES study, Quan et al report that in a cohort of 1,204 adults with OSA randomized to sham or real CPAP and followed longitudinally, there was little detectable difference in cognitive functioning after treatment or sham treatment, suggesting untreated OSA has little effect on cognitive function. Sleep 2011;34:online.

Is polysomnography unnecessary for diagnosis of OSA?

 Sleep, Obesity-related disease  Comments Off on Is polysomnography unnecessary for diagnosis of OSA?
Feb 282011
 

Chai-Coetzer et al designed and validated a predictive model for diagnosing obstructive sleep apnea without polysomnography in 157 general primary care patients considered at average risk for obstructive sleep apnea. Berlin/Epworth questionnaires, snoring, waist size, witnessed apneas and age were fit into an algorithm, followed by home oximetry in a sample of mostly high-Berlin-scoring patients. [… read more]

Long-term outcome and mortality of obesity hypoventilation syndrome

 Review Articles, Sleep, Obesity-related disease  Comments Off on Long-term outcome and mortality of obesity hypoventilation syndrome
Jul 032010
 

Priou et al followed 130 patients with OHS after initiation with noninvasive positive pressure ventilation. Mean follow up was 4 years. Most (96) were started on NPPV in the stable state; 38 had had an acute hypercapneic exacerbation. Survival at 1 year was 97.5%; 2 years (93%); 3 years (88%); 5 years (77%). The large [… read more]