Semenza GL. Oxygen sensing, homeostasis, and disease. NEJM 2011;365:537-547. An acronym-rich summary of decades of work by dozens of investigators eavesdropping on the secret messages cells send in response to hypoxia through HIF-1a, mTOR, VEGF and DMOG. I don’t understand a word of it, frankly. (Review)
Schuetz et al review the 16 randomized controlled trials (n=4,647) testing procalcitonin-guided vs. standard care on the outcomes of antibiotic use, mortality, and infection control. Most of these studies were done in Europe; 6 were in ICU patients. Using procalcitonin reduced antibiotic use in all settings (primary care, emergency department, ICU) with no detectable differences [… read more]
Influenza, RSV, human metapneumovirus, CMV, EBV, herpesviruses, rhinovirus, coronavirus, adenovirus … viruses are increasingly recognized as a cause of pneumonia in adults. Read all about it in this special issue & review. Semin Resp Crit Care Med 2011; 4.
Accountability for Medical Error: Moving Beyond Blame to Advocacy. CHEST 2011;140:519-526. Bell et al’s great essay on the dysfunctional mechanics and culture of liability / safety / blame surrounding medical errors in hospitals and our medical care system in general. They propose steps toward “collective accountability,” e.g., we MDs should sit on hospital safety committees. But [… read more]
Bronchiolitis Obliterans Syndrome: The Final Frontier. No, it’s not the new Star Trek movie featuring a breathless William Shatner. It’s Todd JL, Palmer SM’s review on BOS, the lung transplantation scourge, in CHEST 2011;140:502-508.
12 articles on emergencies (initial management) and postoperative problems. Curr Opin Crit Care 2011;17:317-407. (Special Issue, Review).
The Research Agenda in ICU Telemedicine: A Statement From the Critical Care Societies Collaborative. Kahn JM et al. CHEST 2011;140:230-238.
Rapid response teams. Jones DA et al. NEJM 2011;365:139-146. FULL FREE TEXT
A retrospective review of 521 patients in one Virginia center from 2000-2009, by Nathan SD et al. CHEST 2011;140:221-229
Hyperbaric oxygen in the critically ill. Weaver LK. Crit Care Med 2011;39(7):1784-1791.
Glycemic Control in the ICU. Egi M et al. CHEST 2011;140:212-220. Endocrine, hyperglycemia, review.
Bone Marrow-Derived Stem Cells and Respiratory Disease. Jones CP, Rankin SM. CHEST 2011;140:205-211.
Diseases of the pleura (edited by Richard Light), and neoplasms of the lung (edited by Alan Fein and David Ost). 80 pages. Curr Opin Pulm Med 2011;17(4):215-295.
Airway remodeling and its relationship to inflammation in cystic fibrosis. Regamey N et al. Thorax 2011;66:624-629.
Update on tuberculosis: TB in the early 21st century. Connell DW et al, Eur Resp Rev 2011;20:71-84. FREE FULL TEXT
Improving survival after out-of-hospital cardiac arrest: AHA Consensus Statement. Neumar RW et al. Circulation 2011;123:2898-2910. FREE FULL TEXT. Guideline. Review.
Wrist actigraphy: Martin JL, Hakim AD. CHEST 2011;139:1514-1527.
Potential metabolic consequences of statins in sepsis. Brealy DA et al. Crit Care Med 2011;39:1514-1520.
Pulmonary alveolar proteinosis. Borie R et al, Eur Resp Rev 2011;20:98-107.
Follow-up and nonpharmacological management of the idiopathic pulmonary fibrosis patient. Egan JJ, Eur Resp Rev 2011;20:114-117.