Nov 012011

Karner et al further confirmed the lack of general lack of evidence for "triple therapy" (inhaled corticosteroid, tiotropium, and long-acting beta agonist) for COPD. In a Cochrane analysis, they could only identify one randomized trial (n=293) testing LABA+tiotropium vs. triple-therapy (LABA+tiotropium+ICS). The trial suffered from high and uneven dropout rates between treatment arms, precluding any conclusions.

Karner C et al. The effect of adding inhaled corticosteroids to tiotropium and long-acting beta-agonists for chronic obstructive pulmonary disease. Cochrane Database of Systematic Reviews 2011, Issue 9. Art. No.: CD009039.

A recent retrospective review in CHEST offers positive observational data that triple therapy is beneficial in COPD.

Get our weekly email update, and explore our library of practice updatesreview articles. and board review questions.

PulmCCM is an independent publication not affiliated with or endorsed by any other organization, society or journal referenced on the website. (Terms of Use | Privacy Policy)

Authors: contribute your work in a guest post.


Triple inhaler therapy for COPD?