Apixaban better than aspirin for atrial fib - PulmCCM
Advertisement
Mar 082011
 

Warfarin is the best drug for stroke prevention in atrial fibrillation. In people with a-fib for whom warfarin was unsuitable (unstable INR, unlikely adherence, etc, but excluding those with prior bleeding on warfarin), twice daily oral direct Xa inhibitor apixaban had a hazard ratio of 0.45 over aspirin for the primary outcome of stroke (absolute risk for stroke of 1.6% vs 3.7% per year), with equivalent risk for major bleeding (~1.3% per year, <0.4% for intracranial hemorrhage). The trial was funded by industry, who are also investigating apixaban’s efficacy in treating DVT/PE. (n=5,599). NEJM 2011;364:806-817.

Liked this post? Get a weekly email update (no spam, ever), and explore our library of clinical guidelines, practice updatesreview articles. and board review questions.

PulmCCM is an independent publication, not affiliated with or endorsed by any other organization, society or journal referenced on the website.

Authors: contribute your work to PulmCCM Journal or in a guest blog post.

Leave a Comment