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Taveira-DaSilva reports an observational series of 19 women treated with sirolimus for lymphangioleiomyomatosis. Of 12 women with chylous pleural effusions, most had a large improvement or resolution in their effusions. Ann Intern Med 2011;154:797-805.
In a randomized trial of 89 LAM patients published in NEJM March 2011, sirolimus reduced decline of lung function.